Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine

S Ylä-Herttuala, TT Rissanen, I Vajanto… - Journal of the american …, 2007 - jacc.org
S Ylä-Herttuala, TT Rissanen, I Vajanto, J Hartikainen
Journal of the american college of cardiology, 2007jacc.org
Members of the vascular endothelial growth factor (VEGF) family are among the most
powerful modulators of vascular biology. They regulate vasculogenesis, angiogenesis, and
vascular maintenance during embryogenesis and in adults. Because of their profound
effects on blood vessels, VEGFs have received much attention regarding their potential
therapeutic use in cardiovascular medicine, especially for therapeutic vascular growth in
myocardial and peripheral ischemia. However, completed randomized controlled VEGF …
Members of the vascular endothelial growth factor (VEGF) family are among the most powerful modulators of vascular biology. They regulate vasculogenesis, angiogenesis, and vascular maintenance during embryogenesis and in adults. Because of their profound effects on blood vessels, VEGFs have received much attention regarding their potential therapeutic use in cardiovascular medicine, especially for therapeutic vascular growth in myocardial and peripheral ischemia. However, completed randomized controlled VEGF trials have not provided convincing evidence of clinical efficacy. On the other hand, recent preclinical proangiogenic VEGF studies have given insight, and anti-VEGF studies have shown that the disturbance of vascular homeostasis by blocking VEGF-A may lead to endothelial dysfunction and adverse vascular effects. Excess VEGF-A may contribute to neovascularization of atherosclerotic lesions but, currently, there is no evidence that transient overexpression by gene transfer could lead to plaque destabilization. Here, we review the biology and effects of VEGFs as well as the current status of clinical applications and future perspectives of the therapeutic use of VEGFs in cardiovascular medicine.
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