[HTML][HTML] Lipid segregation and IgE receptor signaling: a decade of progress

D Holowka, JA Gosse, AT Hammond, X Han… - … et Biophysica Acta (BBA …, 2005 - Elsevier
D Holowka, JA Gosse, AT Hammond, X Han, P Sengupta, NL Smith
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2005Elsevier
Recent work to characterize the roles of lipid segregation in IgE receptor signaling has
revealed a mechanism by which segregation of liquid ordered regions from disordered
regions of the plasma membrane results in protection of the Src family kinase Lyn from
inactivating dephosphorylation by a transmembrane tyrosine phosphatase. Antigen-
mediated crosslinking of IgE receptors drives their association with the liquid ordered
regions, commonly called lipid rafts, and this facilitates receptor phosphorylation by active …
Recent work to characterize the roles of lipid segregation in IgE receptor signaling has revealed a mechanism by which segregation of liquid ordered regions from disordered regions of the plasma membrane results in protection of the Src family kinase Lyn from inactivating dephosphorylation by a transmembrane tyrosine phosphatase. Antigen-mediated crosslinking of IgE receptors drives their association with the liquid ordered regions, commonly called lipid rafts, and this facilitates receptor phosphorylation by active Lyn in the raft environment. Previous work showed that the membrane skeleton coupled to F-actin regulates stimulated receptor phosphorylation and downstream signaling processes, and more recent work implicates cytoskeletal interactions with ordered lipid rafts in this regulation. These and other results provide an emerging view of the complex role of membrane structure in orchestrating signal transduction mediated by immune and other cell surface receptors.
Elsevier