Fetal alloantigen is responsible for the expansion of the CD4+ CD25+ regulatory T cell pool during pregnancy
J Zhao, Y Zeng, Y Liu - Journal of reproductive immunology, 2007 - Elsevier
Increasing evidence suggests that CD4+ CD25+ regulatory T cells (Tregs) participate in the
development of maternal tolerance to the fetus during pregnancy; however, the factors
controlling the activities of Tregs are poorly understood. In the present study, CD4+ CD25+
Tregs were analyzed in syngeneically pregnant mice (BALB/c× BALB/c), allogeneically
pregnant mice (BALB/c× C57), ovariectomized mice and pregnant women to investigate the
influences of fetal alloantigens and pregnancy-related hormones on the activities of Tregs. It …
development of maternal tolerance to the fetus during pregnancy; however, the factors
controlling the activities of Tregs are poorly understood. In the present study, CD4+ CD25+
Tregs were analyzed in syngeneically pregnant mice (BALB/c× BALB/c), allogeneically
pregnant mice (BALB/c× C57), ovariectomized mice and pregnant women to investigate the
influences of fetal alloantigens and pregnancy-related hormones on the activities of Tregs. It …