[HTML][HTML] Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase (s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft …
SA Lee, OV Belyaeva, L Wu, NY Kedishvili - Journal of Biological Chemistry, 2011 - ASBMB
Retinoic acid is essential for skin growth and differentiation, and its concentration in skin is
controlled tightly. In humans, four different members of the short-chain dehydrogenase/
reductase (SDR) superfamily of proteins were proposed to catalyze the rate-limiting step in
the biosynthesis of retinoic acid (the oxidation of retinol to retinaldehyde). Epidermis
contains at least three of these enzymes, but their relative importance for retinoic acid
biosynthesis and regulation of gene expression during growth and differentiation of …
controlled tightly. In humans, four different members of the short-chain dehydrogenase/
reductase (SDR) superfamily of proteins were proposed to catalyze the rate-limiting step in
the biosynthesis of retinoic acid (the oxidation of retinol to retinaldehyde). Epidermis
contains at least three of these enzymes, but their relative importance for retinoic acid
biosynthesis and regulation of gene expression during growth and differentiation of …