Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization
Background Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune
responses by delivering potent inhibitory signals to T cells on interaction with specific
ligands expressed on tumor/virus-infected cells, thus contributing to immune escape
mechanisms. Therapeutic PD-1 blockade has been shown to mediate tumor eradication with
impressive clinical results. Little is known about the expression/function of PD-1 on human
natural killer (NK) cells. Objective We sought to clarify whether human NK cells can express …
responses by delivering potent inhibitory signals to T cells on interaction with specific
ligands expressed on tumor/virus-infected cells, thus contributing to immune escape
mechanisms. Therapeutic PD-1 blockade has been shown to mediate tumor eradication with
impressive clinical results. Little is known about the expression/function of PD-1 on human
natural killer (NK) cells. Objective We sought to clarify whether human NK cells can express …