[HTML][HTML] Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer

S Aust, S Felix, K Auer, A Bachmayr-Heyda, L Kenner… - Scientific reports, 2017 - nature.com
S Aust, S Felix, K Auer, A Bachmayr-Heyda, L Kenner, S Dekan, SM Meier, C Gerner
Scientific reports, 2017nature.com
Immune-evasion and immune checkpoints are promising new therapeutic targets for several
cancer entities. In ovarian cancer, the clinical role of programmed cell death receptor ligand
1 (PD-L1) expression as mechanism to escape immune recognition has not been clarified
yet. We analyzed PD-L1 expression of primary ovarian and peritoneal tumor tissues together
with several other parameters (whole transcriptomes of isolated tumor cells, local and
systemic immune cells, systemic cytokines and metabolites) and compared PD-L1 …
Abstract
Immune-evasion and immune checkpoints are promising new therapeutic targets for several cancer entities. In ovarian cancer, the clinical role of programmed cell death receptor ligand 1 (PD-L1) expression as mechanism to escape immune recognition has not been clarified yet. We analyzed PD-L1 expression of primary ovarian and peritoneal tumor tissues together with several other parameters (whole transcriptomes of isolated tumor cells, local and systemic immune cells, systemic cytokines and metabolites) and compared PD-L1 expression between primary tumor and tumor recurrences. All expressed major histocompatibility complex (MHC) I genes were negatively correlated to PD-L1 abundances on tumor tissues, indicating two mutually exclusive immune-evasion mechanisms in ovarian cancer: either down-regulation of T-cell mediated immunity by PD-L1 expression or silencing of self-antigen presentation by down-regulation of the MHC I complex. In our cohort and in most of published evidences in ovarian cancer, low PD-L1 expression is associated with unfavorable outcome. Differences in immune cell populations, cytokines, and metabolites strengthen this picture and suggest the existence of concurrent pathways for progression of this disease. Furthermore, recurrences showed significantly increased PD-L1 expression compared to the primary tumors, supporting trials of checkpoint inhibition in the recurrent setting.
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