[HTML][HTML] NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage
A Peng, PL Chen - Journal of Biological Chemistry, 2003 - ASBMB
Signaling pathways in response to DNA double strand breaks involve molecular cascades
consisting of sensors, transducers, and effector proteins that activate cell cycle checkpoints
and recruit repair machinery proteins. NFBD1 (a nuclearfactor with BRCT domains protein 1)
contains FHA (forkhead–associated), BRCT (breast cancer susceptibility gene 1
carboxylterminus) domains, and internal repeats and is an early participant in nuclear foci in
response to IR. To elucidate its role in the response pathways, small interfering RNA …
consisting of sensors, transducers, and effector proteins that activate cell cycle checkpoints
and recruit repair machinery proteins. NFBD1 (a nuclearfactor with BRCT domains protein 1)
contains FHA (forkhead–associated), BRCT (breast cancer susceptibility gene 1
carboxylterminus) domains, and internal repeats and is an early participant in nuclear foci in
response to IR. To elucidate its role in the response pathways, small interfering RNA …