[HTML][HTML] Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation
W Shi, Z Ma, H Willers, K Akhtar, SP Scott… - Journal of biological …, 2008 - ASBMB
The orderly recruitment, retention, and disassembly of DNA damage response proteins at
sites of damaged DNA is a conserved process throughout eukaryotic evolution. The
recruitment and retention of DNA repair factors in foci is mediated by a complex network of
protein-protein interactions; however, the mechanisms of focus disassembly remain to be
defined. Mediator of DNA damage checkpoint protein 1 (MDC1) is an early and key
component of the genome surveillance network activated by DNA double-strand breaks …
sites of damaged DNA is a conserved process throughout eukaryotic evolution. The
recruitment and retention of DNA repair factors in foci is mediated by a complex network of
protein-protein interactions; however, the mechanisms of focus disassembly remain to be
defined. Mediator of DNA damage checkpoint protein 1 (MDC1) is an early and key
component of the genome surveillance network activated by DNA double-strand breaks …