In search of the tumour-suppressor functions of BRCA1 and BRCA2
R Scully, DM Livingston - Nature, 2000 - nature.com
R Scully, DM Livingston
Nature, 2000•nature.comHereditary breast and ovarian cancer syndromes can be caused by loss-of-function
germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref.). Each
gene product interacts with recombination/DNA repair proteins in pathways that participate
in preserving intact chromosome structure. However, it is unclear to what extent such
functions specifically suppress breast and ovarian cancer. Here we analyse what is known
of BRCA gene function and highlight some unanswered questions in the field.
germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref.). Each
gene product interacts with recombination/DNA repair proteins in pathways that participate
in preserving intact chromosome structure. However, it is unclear to what extent such
functions specifically suppress breast and ovarian cancer. Here we analyse what is known
of BRCA gene function and highlight some unanswered questions in the field.
Abstract
Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref. ). Each gene product interacts with recombination/DNA repair proteins in pathways that participate in preserving intact chromosome structure. However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field.
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