Tau phosphorylation at serine 396 residue is required for hippocampal LTD
Journal of Neuroscience, 2015•Soc Neuroscience
Tau is required for the induction of long-term depression (LTD) of synaptic transmission in
the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor
internalization mechanism is impaired in tau KO mice, and that LTD causes specific
phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that
phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally,
we show that tau KO mice exhibit deficits in spatial reversal learning. These findings …
the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor
internalization mechanism is impaired in tau KO mice, and that LTD causes specific
phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that
phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally,
we show that tau KO mice exhibit deficits in spatial reversal learning. These findings …
Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD.
Soc Neuroscience