Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation.
M Ots, HS Mackenzie, JL Troy… - Journal of the …, 1998 - journals.lww.com
Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists
(AT1RA) slow the rate of progression of experimental renal disease. Although the end result
of both classes of drugs is to block the renin-angiotensin system (RAS), ACEI and AT1RA act
at different sites in the RAS cascade. The aim of this study was to compare the effects of an
ACEI (enalapril) and AT1RA (losartan), alone or in combination, in slowing the progression
of experimental renal disease in a model of reduced renal mass. Two weeks after 5/6 renal …
(AT1RA) slow the rate of progression of experimental renal disease. Although the end result
of both classes of drugs is to block the renin-angiotensin system (RAS), ACEI and AT1RA act
at different sites in the RAS cascade. The aim of this study was to compare the effects of an
ACEI (enalapril) and AT1RA (losartan), alone or in combination, in slowing the progression
of experimental renal disease in a model of reduced renal mass. Two weeks after 5/6 renal …