[HTML][HTML] Diabetic eNOS knockout mice develop distinct macro-and microvascular complications
S Mohan, RL Reddick, N Musi, DA Horn, B Yan… - Laboratory …, 2008 - Elsevier
Functional consequences of impaired endothelial nitric oxide synthase (eNOS) activity
causing organ-specific abnormalities on a diabetic setting are not completely understood. In
this study, we extensively characterized a diabetic mouse model (lepr db/db) in which eNOS
expression is genetically disrupted (eNOS−/−). The eNOS−/−/lepr db/db double-knockout
(DKO) mice developed obesity, hyperglycemia, hyperinsulinemia and hypertension.
Analysis of tissues from DKO mice showed large islets in the pancreas and fat droplets in …
causing organ-specific abnormalities on a diabetic setting are not completely understood. In
this study, we extensively characterized a diabetic mouse model (lepr db/db) in which eNOS
expression is genetically disrupted (eNOS−/−). The eNOS−/−/lepr db/db double-knockout
(DKO) mice developed obesity, hyperglycemia, hyperinsulinemia and hypertension.
Analysis of tissues from DKO mice showed large islets in the pancreas and fat droplets in …