Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

A Rasola, P Bernardi - Cell calcium, 2011 - Elsevier
A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second
messenger to transmit signals, through Ca2+ release from the endoplasmic reticulum or
opening of plasma membrane Ca2+ channels. Mitochondria contribute to the tight
spatiotemporal control of this process by accumulating Ca2+, thus shaping the return of
cytosolic Ca2+ to resting levels. The rise of mitochondrial matrix free Ca2+ concentration
stimulates oxidative metabolism; yet, in the presence of a variety of sensitizing factors of …