[PDF][PDF] Innate immune recognition of mtDNA—an undercover signal?
Cell metabolism, 2015•cell.com
In addition to their roles in cellular metabolism and apoptosis, mitochondria function as
signaling platforms in the innate immune response. In Nature, West et al.(2015) demonstrate
that mitochondrial stress triggers a type I interferon response and confers viral resistance via
release of mtDNA and activation of the cGAS–STING pathway.
signaling platforms in the innate immune response. In Nature, West et al.(2015) demonstrate
that mitochondrial stress triggers a type I interferon response and confers viral resistance via
release of mtDNA and activation of the cGAS–STING pathway.
In addition to their roles in cellular metabolism and apoptosis, mitochondria function as signaling platforms in the innate immune response. In Nature, West et al. (2015) demonstrate that mitochondrial stress triggers a type I interferon response and confers viral resistance via release of mtDNA and activation of the cGAS–STING pathway.
cell.com