The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia
MBE Schaaf, D Cojocari, TG Keulers, B Jutten… - Radiotherapy and …, 2013 - Elsevier
Background and purpose Tumor hypoxia is associated with therapy resistance and
malignancy. Previously we demonstrated that activation of autophagy and the unfolded
protein response (UPR) promote hypoxia tolerance. Here we explored the importance of
ULK1 in hypoxia tolerance, autophagy induction and its prognostic value for recurrence after
treatment. Material and methods Hypoxic regulation of ULK1 mRNA and protein was
assessed in vitro and in primary human head and neck squamous cell carcinoma (HNSCC) …
malignancy. Previously we demonstrated that activation of autophagy and the unfolded
protein response (UPR) promote hypoxia tolerance. Here we explored the importance of
ULK1 in hypoxia tolerance, autophagy induction and its prognostic value for recurrence after
treatment. Material and methods Hypoxic regulation of ULK1 mRNA and protein was
assessed in vitro and in primary human head and neck squamous cell carcinoma (HNSCC) …