[HTML][HTML] A multi‐stage multi‐design strategy provides strong evidence that the BAI3 locus is associated with early‐onset venous thromboembolism
G Antoni, PE MORANGE, Y Luo, N Saut… - Journal of Thrombosis …, 2010 - Elsevier
Summary Background: Factor VIII (FVIII) and von Willebrand factor (VWF) are two known
quantitative risk factors for venous thromboembolism (VTE). Objectives: To identify new loci
that could contribute to VTE susceptibility and to modulating FVIII and/or VWF levels.
Patients/Methods: A pedigree linkage analysis was first performed in five extended French‐
Canadian families, including 253 individuals, to identify genomic regions linked to FVIII or
VWF levels. Identified regions were further explored using 'in silico'genome‐wide …
quantitative risk factors for venous thromboembolism (VTE). Objectives: To identify new loci
that could contribute to VTE susceptibility and to modulating FVIII and/or VWF levels.
Patients/Methods: A pedigree linkage analysis was first performed in five extended French‐
Canadian families, including 253 individuals, to identify genomic regions linked to FVIII or
VWF levels. Identified regions were further explored using 'in silico'genome‐wide …