5-fluorouracil: mechanisms of action and clinical strategies
DB Longley, DP Harkin, PG Johnston - Nature reviews cancer, 2003 - nature.com
DB Longley, DP Harkin, PG Johnston
Nature reviews cancer, 2003•nature.comFluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of
strategies that increase its anticancer activity. Despite these advances, drug resistance
remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as
DNA microarray profiling, have the potential to identify novel genes that are involved in
mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable …
increased understanding of the mechanism of action of 5-FU has led to the development of
strategies that increase its anticancer activity. Despite these advances, drug resistance
remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as
DNA microarray profiling, have the potential to identify novel genes that are involved in
mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable …
Abstract
5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as DNA microarray profiling, have the potential to identify novel genes that are involved in mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy.
nature.com