Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy
SR Barbari, PV Shcherbakova - DNA repair, 2017 - Elsevier
The fidelity of DNA replication relies on three error avoidance mechanisms acting in series:
nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-
replicative DNA mismatch repair (MMR). MMR defects are well known to be associated with
increased cancer incidence. Due to advances in DNA sequencing technologies, the past
several years have witnessed a long-predicted discovery of replicative DNA polymerase
defects in sporadic and hereditary human cancers. The polymerase mutations preferentially …
nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-
replicative DNA mismatch repair (MMR). MMR defects are well known to be associated with
increased cancer incidence. Due to advances in DNA sequencing technologies, the past
several years have witnessed a long-predicted discovery of replicative DNA polymerase
defects in sporadic and hereditary human cancers. The polymerase mutations preferentially …