Human cancers express mutator phenotypes: origin, consequences and targeting
LA Loeb - Nature Reviews Cancer, 2011 - nature.com
Nature Reviews Cancer, 2011•nature.com
Recent data on DNA sequencing of human tumours have established that cancer cells
contain thousands of mutations. These data support the concept that cancer cells express a
mutator phenotype. This Perspective considers the evidence supporting the mutator
phenotype hypothesis, the origin and consequences of a mutator phenotype, the
implications for personalized medicine and the feasibility of ablating tumours by error
catastrophe.
contain thousands of mutations. These data support the concept that cancer cells express a
mutator phenotype. This Perspective considers the evidence supporting the mutator
phenotype hypothesis, the origin and consequences of a mutator phenotype, the
implications for personalized medicine and the feasibility of ablating tumours by error
catastrophe.
Abstract
Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.
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