DNA mismatch repair and its many roles in eukaryotic cells
D Liu, G Keijzers, LJ Rasmussen - Mutation Research/Reviews in Mutation …, 2017 - Elsevier
DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute
significantly to the viability of cells and organisms. MMR is widely-used as a diagnostic
biomarker for human cancers in the clinic, and as a biomarker of cancer susceptibility in
animal model systems. Prokaryotic MMR is well-characterized at the molecular and
mechanistic level; however, MMR is considerably more complex in eukaryotic cells than in …
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute
significantly to the viability of cells and organisms. MMR is widely-used as a diagnostic
biomarker for human cancers in the clinic, and as a biomarker of cancer susceptibility in
animal model systems. Prokaryotic MMR is well-characterized at the molecular and
mechanistic level; however, MMR is considerably more complex in eukaryotic cells than in …