NAD (H) in mitochondrial energy transduction: implications for health and disease
MA Walker, R Tian - Current opinion in physiology, 2018 - Elsevier
Highlights•The intracellular NAD (H) pool is central to mitochondrial energy
transduction.•NAD+ is a co-substrate for enzymes involved in stress response and cell
signaling.•NAD+ depletion and redox imbalance are implicated in a wide spectrum of
diseases.•Raising NAD+ levels have tremendous potential as a therapy to treat human
disease.Mitochondria are intracellular organelles that oxidize nutrients, make ATP, and fuel
eukaryotic life. Their energy providing function is directly dependent on enzymes and …
transduction.•NAD+ is a co-substrate for enzymes involved in stress response and cell
signaling.•NAD+ depletion and redox imbalance are implicated in a wide spectrum of
diseases.•Raising NAD+ levels have tremendous potential as a therapy to treat human
disease.Mitochondria are intracellular organelles that oxidize nutrients, make ATP, and fuel
eukaryotic life. Their energy providing function is directly dependent on enzymes and …