[HTML][HTML] The role of the insulin-like growth factor-1 system in breast cancer
Molecular cancer, 2015•Springer
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-
apoptotic events. Although many of the relevant molecular pathways and intracellular
cascades remain to be elucidated, a growing body of evidence points to the important role of
the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point
of convergence for major signaling pathways implicated in breast cancer growth. In this …
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-
apoptotic events. Although many of the relevant molecular pathways and intracellular
cascades remain to be elucidated, a growing body of evidence points to the important role of
the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point
of convergence for major signaling pathways implicated in breast cancer growth. In this …
Abstract
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
Springer