[HTML][HTML] SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion
K Sadoul, A Berger, H Niemann, U Weller… - Journal of Biological …, 1997 - ASBMB
The synaptosomal-associated protein of 25 kDa (SNAP-25) is expressed in neurons and
endocrine cells. It has been shown to play an important role in the release mechanism of
neurotransmitters and peptide hormones, including insulin. Thus, when insulin-secreting
cells are permeabilized and treated with botulinum neurotoxin E (BoNT/E), SNAP-25 is
hydrolyzed, and insulin secretion is inhibited. Recently SNAP-23, a more generally
expressed isoform of SNAP-25, has been described. The functional role of SNAP-23 has not …
endocrine cells. It has been shown to play an important role in the release mechanism of
neurotransmitters and peptide hormones, including insulin. Thus, when insulin-secreting
cells are permeabilized and treated with botulinum neurotoxin E (BoNT/E), SNAP-25 is
hydrolyzed, and insulin secretion is inhibited. Recently SNAP-23, a more generally
expressed isoform of SNAP-25, has been described. The functional role of SNAP-23 has not …