[HTML][HTML] CD28-specific immunomodulating antibodies: what can be learned from experimental models?

N Poirier, G Blancho, B Vanhove - American Journal of Transplantation, 2012 - Elsevier
Tolerance induction to alloantigens remains a major challenge in transplant immunology.
Progress in the last decade of our understanding of T-cell activation has led to the
development of new immunotherapeutic strategies to replace conventional
immunosuppression which inhibits the immune system in a nonspecific way. In particular,
positive and negative costimulatory molecules of the CD28 family have been consistently
demonstrated to be critical for the development of productive immune responses as well as …