Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with Belatacept mediated CD28–CD80/86 blockade
H Chavez, S Beaudreuil, K Abbed, Y Taoufic… - Transplant …, 2007 - Elsevier
AIMS: Belatacept is a new recombinant molecule (CTLA4-Ig) that interferes with the second
activation signal of T lymphocytes. CTLA4-Ig induced T cell allograft tolerance in rodents but
not in primates. We examined the changes in peripheral lymphocyte subsets, including
regulatory T cells, in renal transplant patients treated with Belatacept. METHODS: A cross-
sectional immunological study was carried out 6 months after transplantation in 28 patients
enrolled in the Belatacept phase II study. Eighteen patients received Belatacept …
activation signal of T lymphocytes. CTLA4-Ig induced T cell allograft tolerance in rodents but
not in primates. We examined the changes in peripheral lymphocyte subsets, including
regulatory T cells, in renal transplant patients treated with Belatacept. METHODS: A cross-
sectional immunological study was carried out 6 months after transplantation in 28 patients
enrolled in the Belatacept phase II study. Eighteen patients received Belatacept …