Despite extensive research on the trafficking of anandamide (AEA) across cell membranes,
little is known about the membrane transport of other endocannabinoids, such as 2-
arachidonoylglycerol (2-AG). Previous studies have provided data both in favor and against
a cell membrane carrier-mediated transport of endocannabinoids, using different
methodological approaches. Because AEA and 2-AG undergo rapid and almost complete
intracellular hydrolysis, we employed a combination of radioligand assays and absolute …