[HTML][HTML] A mutation in the surfactant protein C gene associated with familial interstitial lung disease

LM Nogee, AE Dunbar, SE Wert, F Askin… - … England Journal of …, 2001 - Mass Medical Soc
LM Nogee, AE Dunbar, SE Wert, F Askin, A Hamvas, JA Whitsett
New England Journal of Medicine, 2001Mass Medical Soc
Interstitial lung diseases are a heterogeneous group of disorders that are poorly understood
at a molecular level. 1, 2 The cause is often unknown, and the histologic diagnoses used in
adults may represent different disease processes in children. 3–5 For example, cases of
desquamative interstitial pneumonitis reported in infants are often more severe and
refractory to treatment than those reported in adults. 6, 7 Many of these cases probably
represent chronic pneumonitis of infancy. 8, 9 The lungs in patients with chronic pneumonitis …
Interstitial lung diseases are a heterogeneous group of disorders that are poorly understood at a molecular level.1,2 The cause is often unknown, and the histologic diagnoses used in adults may represent different disease processes in children.35 For example, cases of desquamative interstitial pneumonitis reported in infants are often more severe and refractory to treatment than those reported in adults.6,7 Many of these cases probably represent chronic pneumonitis of infancy.8,9 The lungs in patients with chronic pneumonitis of infancy are characterized by interstitial thickening with mesenchymal cells, rather than by an inflammatory infiltrate, and an alveolar infiltrate . . .
The New England Journal Of Medicine