Genetics of human sleep behavioral phenotypes

PK Hsu, LJ Ptįček, YH Fu - Methods in enzymology, 2015 - Elsevier
Quality sleep is critical for daily functions of human beings and thus the timing and duration
of sleep are tightly controlled. However, rare genetic variants affecting sleep regulatory
mechanisms can result in sleep phenotypes of extremely deviated sleep/wake onset time or
duration. Using genetic analyses in families with multiple members expressing particular
sleep phenotypes, these sleep-associated genetic variants can be identified. Deciphering
the nature of these genetic variants using animal models or biochemical methods helps …