[HTML][HTML] Immunity to the respiratory pathogen Bordetella pertussis

R Higgs, SC Higgins, PJ Ross, KHG Mills - Mucosal immunology, 2012 - Elsevier
Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants
and children, and also infects adults. Studies in murine models have shown that innate
immune mechanisms involving dendritic cells, macrophages, neutrophils, natural killer cells,
and antimicrobial peptides help to control the infection, while complete bacterial clearance
requires cellular immunity mediated by T-helper type 1 (Th1) and Th17 cells. Whole cell
pertussis vaccines (wP) are effective, but reactogenic, and have been replaced in most …