[HTML][HTML] Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis
Allergic asthma is a chronic inflammatory disorder of the airways that affects> 300 million
people worldwide. The pro-inflammatory cytokines interleukin (IL)-1α and IL-1β have
essential roles in the pathogenesis of asthma. However, the mechanisms underlying the
production of IL-1 cytokines in allergic asthma remain unclear. In this study, we used a
mouse model of ovalbumin-induced asthma to identify a crucial role for caspase-8 in the
development of allergic airway inflammation. We further demonstrated that hematopoietic …
people worldwide. The pro-inflammatory cytokines interleukin (IL)-1α and IL-1β have
essential roles in the pathogenesis of asthma. However, the mechanisms underlying the
production of IL-1 cytokines in allergic asthma remain unclear. In this study, we used a
mouse model of ovalbumin-induced asthma to identify a crucial role for caspase-8 in the
development of allergic airway inflammation. We further demonstrated that hematopoietic …