Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse

F Ko, P Abadir, R Marx, R Westbrook, C Cooke… - Experimental …, 2016 - Elsevier
Mitochondrial dysfunction, chronic inflammation and muscle aging are closely linked.
Mitochondrial clearance is a process to dampen inflammation and is a critical pre-requisite
to mitobiogenesis. The combined effect of aging and chronic inflammation on mitochondrial
degradation by autophagy is understudied. In interleukin 10 null mouse (IL-10 tm/tm), a
rodent model of chronic inflammation, we studied the effects of aging and inflammation on
mitochondrial clearance. We show that aging in IL-10 tm/tm is associated with reduced …