[HTML][HTML] Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species
Y Li, P Zhang, C Wang, C Han, J Meng, X Liu… - Journal of Biological …, 2013 - ASBMB
Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the
death of septic patients at the late stage because of the decreased innate immunity with a
more opportunistic infection. LPS-tolerized macrophages, which are re-challenged by LPS
after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for
SAIS. However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be
fully elucidated. In addition, negative regulation of the Toll-like receptor (TLR)-triggered …
death of septic patients at the late stage because of the decreased innate immunity with a
more opportunistic infection. LPS-tolerized macrophages, which are re-challenged by LPS
after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for
SAIS. However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be
fully elucidated. In addition, negative regulation of the Toll-like receptor (TLR)-triggered …