[PDF][PDF] Orchestration of metabolism by macrophages

SK Biswas, A Mantovani - Cell metabolism, 2012 - cell.com
Cell metabolism, 2012cell.com
Metabolic adaptation is a key component of macrophage plasticity and polarization,
instrumental to their function in homeostasis, immunity, and inflammation. Macrophage
products also impact metabolism, as illustrated by obesity-associated pathologies. Defining
the mechanisms regulating macrophage metabolic activity and orchestration of metabolism
by macrophages is crucial to pathology and therapeutic intervention.
Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity, and inflammation. Macrophage products also impact metabolism, as illustrated by obesity-associated pathologies. Defining the mechanisms regulating macrophage metabolic activity and orchestration of metabolism by macrophages is crucial to pathology and therapeutic intervention.
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