The spared nerve injury model of neuropathic pain

M Pertin, RD Gosselin, I Decosterd - Pain Research: Methods and …, 2012 - Springer
M Pertin, RD Gosselin, I Decosterd
Pain Research: Methods and Protocols, 2012Springer
The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral
nerve injury and is based upon an invasive but simple surgical procedure. Since its first
description in 2000, it has displayed a remarkable development. It produces a robust,
reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as
well as the possibility of studying both injured and non-injured neuronal populations in the
same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice …
Abstract
The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.
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