Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons
K Noguchi, K Kowalski, R Traub, A Solodkin… - Molecular Brain …, 1991 - Elsevier
Fos and Fos-related proteins are increased in spinal dorsal horn neurons following noxious
stimulation. The laminar location of neurons that exhibit this increase is coincident with those
that exhibit an increase in dynorphin in a rat model of peripheral inflammation and
hyperalgesia. In order to determine whether the increase in Fos or related proteins and
dynorphin occurs in the same dorsal horn neurons, two kinds of double-labeling methods
were used: in situ hybridization histochemistry to label dynorphin mRNA …
stimulation. The laminar location of neurons that exhibit this increase is coincident with those
that exhibit an increase in dynorphin in a rat model of peripheral inflammation and
hyperalgesia. In order to determine whether the increase in Fos or related proteins and
dynorphin occurs in the same dorsal horn neurons, two kinds of double-labeling methods
were used: in situ hybridization histochemistry to label dynorphin mRNA …