[PDF][PDF] The expression of vesicular glutamate transporters defines two classes of excitatory synapse

RT Fremeau, MD Troyer, I Pahner, GO Nygaard… - Neuron, 2001 - cell.com
RT Fremeau, MD Troyer, I Pahner, GO Nygaard, CH Tran, RJ Reimer, EE Bellocchio…
Neuron, 2001cell.com
The quantal release of glutamate depends on its transport into synaptic vesicles. Recent
work has shown that a protein previously implicated in the uptake of inorganic phosphate
across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However,
only a subset of glutamate neurons expresses this vesicular glutamate transporter
(VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related
protein that has also been implicated in phosphate transport. Like VGLUT1, this protein …
Abstract
The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse.
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