Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis

M Pérez-Carreras, P Del Hoyo, MA Martı́n, JC Rubio… - Hepatology, 2003 - Elsevier
Mitochondrial dysfunction might play a central role in the pathogenesis of nonalcoholic
steatohepatitis (NASH). The aims of this study were to evaluate whether free fatty acid (FFA)
transport into the mitochondria or the activity of mitochondria respiratory chain (MRC)
complexes are impaired in NASH. In patients with NASH and control subjects, we measured
free carnitine, short-chain acylcarnitine (SCAC) and long-chain acylcarnitine (LCAC) esters,
carnitine palmitoyltransferase (CPT) activity, and MRC enzyme activity in liver tissue as well …