Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese …
BACKGROUND & AIMS: In this study, we sought to determine the temporal relationship
between hepatic mitochondrial dysfunction, hepatic steatosis and insulin resistance, and to
examine their potential role in the natural progression of non-alcoholic fatty liver disease
(NAFLD) utilising a sedentary, hyperphagic, obese, Otsuka Long–Evans Tokushima Fatty
(OLETF) rat model. METHODS: OLETF rats and their non-hyperphagic control Long–Evans
Tokushima Otsuka (LETO) rats were sacrificed at 5, 8, 13, 20, and 40weeks of age (n= 6–8 …
between hepatic mitochondrial dysfunction, hepatic steatosis and insulin resistance, and to
examine their potential role in the natural progression of non-alcoholic fatty liver disease
(NAFLD) utilising a sedentary, hyperphagic, obese, Otsuka Long–Evans Tokushima Fatty
(OLETF) rat model. METHODS: OLETF rats and their non-hyperphagic control Long–Evans
Tokushima Otsuka (LETO) rats were sacrificed at 5, 8, 13, 20, and 40weeks of age (n= 6–8 …