Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
AE Feldstein, A Canbay, ME Guicciardi, H Higuchi… - Journal of …, 2003 - Elsevier
Background/Aims: Hepatic steatosis sensitizes the liver to injury and inflammation by
unclear mechanisms. Because Fas has been linked to liver injury and inflammation, Fas
expression and sensitization to Fas signaling was examined in models of hepatic steatosis.
Methods: Mice were fed a carbohydrate diet while control animals received standard chow.
Sensitization to Fas was examined following administration of Jo2 antibody. For the in vitro
experiments, HepG2 cells were incubated with or without a mixture of long chain fatty acids …
unclear mechanisms. Because Fas has been linked to liver injury and inflammation, Fas
expression and sensitization to Fas signaling was examined in models of hepatic steatosis.
Methods: Mice were fed a carbohydrate diet while control animals received standard chow.
Sensitization to Fas was examined following administration of Jo2 antibody. For the in vitro
experiments, HepG2 cells were incubated with or without a mixture of long chain fatty acids …