[HTML][HTML] A common variant in the peroxisome proliferator–activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children

YC Lin, PF Chang, MH Chang, YH Ni - The American journal of clinical …, 2013 - Elsevier
Background: The single nucleotide polymorphism in the peroxisome proliferator–activated
receptor-γ coactivator (PGC)-1α gene (PPARGC1A) was identified to be associated with
nonalcoholic fatty liver disease (NAFLD) in adults. The PPARGC1A gene encodes PGC-1α,
which regulates cellular energy metabolism. Objective: We aimed to test the hypothesis that
the PPARGC1A rs8192678 risk A allele would influence the risk of NAFLD in obese
children. Design: We genotyped PPARGC1A rs8192678 and PNPLA3 rs738409 in 781 …