HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation
Y Liu, Z Ma, C Zhao, Y Wang, G Wu, J Xiao… - Toxicology letters, 2014 - Elsevier
During periods of cellular hypoxia, hepatocytes adapt to consume less oxygen by shifting
energy production from mitochondrial fatty acid β-oxidation to glycolysis. One of the earliest
responses to pathologic hypoxia is the activation of the hypoxia-inducible factor (HIF). In the
present study, we examined whether HIF-1 and HIF-2 were involved in the regulation of fatty
acid synthesis and β-oxidation. We showed that hypoxia induced fat accumulation in the
livers of mice and in HepG2 cells. These hypoxia-induced changes in fatty acid metabolism …
energy production from mitochondrial fatty acid β-oxidation to glycolysis. One of the earliest
responses to pathologic hypoxia is the activation of the hypoxia-inducible factor (HIF). In the
present study, we examined whether HIF-1 and HIF-2 were involved in the regulation of fatty
acid synthesis and β-oxidation. We showed that hypoxia induced fat accumulation in the
livers of mice and in HepG2 cells. These hypoxia-induced changes in fatty acid metabolism …