The genetics of pediatric nonalcoholic fatty liver disease

NP Goyal, JB Schwimmer - Clinics in liver disease, 2018 - liver.theclinics.com
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in
children. The prevalence of fatty liver, after adjusting for age, race, gender, and ethnicity, is
estimated at 9.6%. 1 Pediatric nonalcoholic steatohepatitis (NASH) can be distinct from adult
NASH and denotes hepatic steatosis with inflammation, with or without ballooning injury to
hepatocytes. 2 This can include zone 3 (venule)–centered injury pattern or confluent pattern
typically with ballooning or portal predominant (zone 1)–centered injury pattern often without …