The pathogenesis and treatment of nonalcoholic steatohepatitis (NASH) are not well
established. Feeding a diet deficient in both methionine and choline (MCD) is one of the
most common models of NASH, which is characterized by steatosis, mitochondrial
dysfunction, hepatocellular injury, oxidative stress, inflammation, and fibrosis. However, the
individual contribution of the lack of methionine and choline in liver steatosis, advanced
pathology and impact on mitochondrial S-adenosyl-l-methionine (SAM) and glutathione …