[HTML][HTML] Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

C Riehle, AR Wende, S Sena, KM Pires… - The Journal of …, 2013 - Am Soc Clin Investig
C Riehle, AR Wende, S Sena, KM Pires, RO Pereira, Y Zhu, H Bugger, D Frank, J Bevins…
The Journal of clinical investigation, 2013Am Soc Clin Investig
The induction of autophagy in the mammalian heart during the perinatal period is an
essential adaptation required to survive early neonatal starvation; however, the mechanisms
that mediate autophagy suppression once feeding is established are not known. Insulin
signaling in the heart is transduced via insulin and IGF-1 receptors (IGF-1Rs). We disrupted
insulin and IGF-1R signaling by generating mice with combined cardiomyocyte-specific
deletion of Irs1 and Irs2. Here we show that loss of IRS signaling prevented the …
The induction of autophagy in the mammalian heart during the perinatal period is an essential adaptation required to survive early neonatal starvation; however, the mechanisms that mediate autophagy suppression once feeding is established are not known. Insulin signaling in the heart is transduced via insulin and IGF-1 receptors (IGF-1Rs). We disrupted insulin and IGF-1R signaling by generating mice with combined cardiomyocyte-specific deletion of Irs1 and Irs2. Here we show that loss of IRS signaling prevented the physiological suppression of autophagy that normally parallels the postnatal increase in circulating insulin. This resulted in unrestrained autophagy in cardiomyocytes, which contributed to myocyte loss, heart failure, and premature death. This process was ameliorated either by activation of mTOR with aa supplementation or by genetic suppression of autophagic activation. Loss of IRS1 and IRS2 signaling also increased apoptosis and precipitated mitochondrial dysfunction, which were not reduced when autophagic flux was normalized. Together, these data indicate that in addition to prosurvival signaling, insulin action in early life mediates the physiological postnatal suppression of autophagy, thereby linking nutrient sensing to postnatal cardiac development.
The Journal of Clinical Investigation