Metabolic rate and the subsequent production of reactive oxygen species are thought to
contribute to the rate of aging in a wide range of species. The target of rapamycin (TOR) is a
well conserved serine/threonine kinase that regulates cell growth in response to nutrient
status. Here we demonstrate that in mammalian cells the mammalian TOR (mTOR) pathway
plays a significant role in determining both resting oxygen consumption and oxidative
capacity. In particular, we demonstrate that the level of complex formation between mTOR …