[HTML][HTML] The insulin receptor and its signal transduction network
P De Meyts - Endotext [Internet], 2016 - ncbi.nlm.nih.gov
Endotext [Internet], 2016•ncbi.nlm.nih.gov
Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting
through a receptor located in the membrane of target cells-major ones being liver (where it
promotes glucose storage into glycogen and decreases glucose output), as well as skeletal
muscle and fat (where it stimulates glucose transport through translocation of GLUT4), but
also b cells, brain cells and in fact most cells, where it has pleiotropic effects.
through a receptor located in the membrane of target cells-major ones being liver (where it
promotes glucose storage into glycogen and decreases glucose output), as well as skeletal
muscle and fat (where it stimulates glucose transport through translocation of GLUT4), but
also b cells, brain cells and in fact most cells, where it has pleiotropic effects.
Abstract
Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting through a receptor located in the membrane of target cells-major ones being liver (where it promotes glucose storage into glycogen and decreases glucose output), as well as skeletal muscle and fat (where it stimulates glucose transport through translocation of GLUT4), but also b cells, brain cells and in fact most cells, where it has pleiotropic effects.
ncbi.nlm.nih.gov