[PDF][PDF] Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony …

P Filipazzi, R Valenti, V Huber, L Pilla… - Journal of clinical …, 2007 - researchgate.net
P Filipazzi, R Valenti, V Huber, L Pilla, P Canese, M Iero, C Castelli, L Mariani, G Parmiani…
Journal of clinical oncology, 2007researchgate.net
Purpose Phenotypic and functional features of myeloid suppressor cells (MSC), which are
known to serve as critical regulators of antitumor T-cell responses in tumor-bearing mice, are
still poorly defined in human cancers. Here, we analyzed myeloid subsets with suppressive
activity present in peripheral blood of metastatic melanoma patients and evaluated their
modulation by a granulocyte-macrophage colonystimulating factor (GM-CSF)–based
antitumor vaccine.
Purpose
Phenotypic and functional features of myeloid suppressor cells (MSC), which are known to serve as critical regulators of antitumor T-cell responses in tumor-bearing mice, are still poorly defined in human cancers. Here, we analyzed myeloid subsets with suppressive activity present in peripheral blood of metastatic melanoma patients and evaluated their modulation by a granulocyte-macrophage colonystimulating factor (GM-CSF)–based antitumor vaccine.
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