Pan-Trk immunohistochemistry is an efficient and reliable screen for the detection of NTRK fusions
JF Hechtman, R Benayed, DM Hyman… - The American journal …, 2017 - journals.lww.com
Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using
nucleic-acid based assays, are highly targetable and define certain tumors. Here, we
explore the utility of pan-TRK immunohistochemistry (IHC) to detect NTRK fusions. NTRK
rearrangements were detected prospectively using MSK-IMPACT, a DNA-based next-
generation sequencing assay. Transcription of novel NTRK rearrangements into potentially
functional fusion transcripts was assessed via Archer Dx fusion assay. Pan-Trk IHC testing …
nucleic-acid based assays, are highly targetable and define certain tumors. Here, we
explore the utility of pan-TRK immunohistochemistry (IHC) to detect NTRK fusions. NTRK
rearrangements were detected prospectively using MSK-IMPACT, a DNA-based next-
generation sequencing assay. Transcription of novel NTRK rearrangements into potentially
functional fusion transcripts was assessed via Archer Dx fusion assay. Pan-Trk IHC testing …