[HTML][HTML] Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation

X Liu, W Huang, C Li, P Li, J Yuan, X Li, XB Qiu, Q Ma… - Molecular cell, 2006 - cell.com
X Liu, W Huang, C Li, P Li, J Yuan, X Li, XB Qiu, Q Ma, C Cao
Molecular cell, 2006cell.com
Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The
present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate
with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently,
proteasome-dependent proteolysis is compromised. Notably, cells expressing a
phosphorylation mutant of PSMA7 (Y153F) display impaired G1/S transition and S/G2
progression, highlighting the biological significance of tyrosine phosphorylation of a …
Summary
Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control.
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