[HTML][HTML] Resolvin D1 and its aspirin-triggered 17R epimer: stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation

YP Sun, SF Oh, J Uddin, R Yang, K Gotlinger… - Journal of Biological …, 2007 - ASBMB
We recently uncovered two new families of potent docosahexaenoic acid-derived mediators,
termed D series resolvins (Rv; resolution phase interaction products) and protectins. Here,
we assign the stereochemistry of the conjugated double bonds and chirality of alcohols
present in resolvin D1 (RvD1) and its aspirin-triggered 17R epimer (AT-RvD1) with
compounds prepared by total organic synthesis. In addition, docosahexaenoic acid was
converted by a single lipoxygenase in a" one-pot" reaction to RvD1 in vitro. The synthetic …